Program
- September 25 (UCT Prague, Technicka 5, room A I)
- 17:00
- GPCRdb/GPCRmd collaborators meeting
- September 26 (National Library of Technology, Technická 6, Baling hall)
- 9:00
- Welcome
- 9:15
- Update on Glisten by Peter Kolb
- 9:30
- David Rees (Astex Pharmaceuticals) Fragment Based Drug Discovery - Case History
- 10:05
- Didier Rognan (Uni Strasbourg) Allosteric Inhibition of a Class F GPCR, Smoothened: From Theory to Practice
- 10:40
- Noureldin Saleh (FAU Erlangen) The Cooperative Mechanism of Activation and Control of G-protein Coupled Receptors
- 11:15
- Coffee break
- 11:45
- Christofer Tautermann (Boehringer Ingelheim) Explaining the Binding of Anticholinergics to the M3 Receptor by Mutagenesis Experiments and MD Simulations
- 12:20
- Young Glisteners
- 13:20
- Lunch + Poster session
- in parallel
- 13:20
- Meet & greet (TIME CHANGED!)
- 15:20
- Stefano Moro (Uni Padova) New Insights in Agonists and Antagonists Recognition by Adenosine Receptors
- 15:55
- Jonathan S. Mason (Heptares Therapeutics) High End GPCR Design: Experimental and Computational Insights into GPCR Structures and the Key Role of Waters for Potency, Selectivity & Kinetics
- 16:30
- Coffee break
- 17:00
- Jillian Baker (Uni Nothingam) Academic Drug Discovery – New Thoughts on beta-Blockers
- 17:35
- Andrea Cavalli (Uni Bologna) Thermodynamics and Kinetics of Drug-Target Binding Through Molecular Simulations
- 18:10
- Marton Vass (VU Amsterdam) 3D-e-Chem: An Integrated Cheminformatics Platform. Case Studies on GPCR Bioactivity Data
- 18:25
- Mar Puigdellivol (Uni East Anglia) Dopamine D1-histamine H3 Receptor Heteromers: A New Therapeutic Target in Huntington's Disease
- 18:40
- Dinner + microbrewery excursion
- September 27 (National Library of Technology, Technická 6, Baling hall)
- 8:30
- GPCRdb demo
- 9:00
- Hans Bräuner-Osborne (Uni Copenhagen) Total Synthesis and Pharmacological Characterization of Gq Inhibitors YM-254890, FR900359 and Analogs Hereof
- 9:35
- Christoffer Clemmensen (Helmholtz Diabetes Center Munich) Unimolecular Polypharmacy for Treatment of Metabolic Diseases
- 10:10
- Daniel Fourmy (INSERM Toulouse) Biased and Endosomal Signaling of the Glucose-Dependent Insulinotropic Receptor (GIPR)
- 10:45
- Coffee break
- 11:15
- Alexey Bondar (Czech Academy of Sciences, Nové Hrady) Assembly of G Proteins with GPCRs Uncovered by Two-Photon Polarization Microscopy
- 11:50
- Nuska Tschammer (NanoTemper Technologies) G Protein Coupled Receptors: Biomolecular Interaction Analysis using MicroScale Thermophoresis
- 12:25
- Lunch + Poster session
- in parallel
- 14:00
- MC meeting
- 15:30
- Dmitry Veprintsev (PSI Villigen) Molecular Basis for G Protein Activation
- 16:05
- Franziska M. Heydenreich (PSI Villigen) The Inner Workings of a GPCR: Mechanisms of G Protein Activation and β-Arrestin Recruitment
- 16:20
- Masha Niv (Hebrew University of Jerusalem) Predicting and Tasting Ligands of T2R GPCRs
- 16:55
- Poster award, closing